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- W2380703600 abstract "Objective To study the anticoagulant and fibrinolytic mechanism of vascular endothelial cells in rabbit model of blood stasis syndrome (BSS). Methods BS S rabbit model was induced by injection of noradrenaline and bovine serum albumin . The aortic endothelial cells from the normal rabbits (Group A)and BSS rabbits (Group B)were cultured primarily and subcultured. The activities of antithrombin Ⅲ (AT_Ⅲ), tis sue_type plasminogen activator (t_PA) and plasminogen activator inhibitor (PAI) in the plasma of rabbits and cultured supernatant were measured. Results The activities of t_PA and AT_Ⅲ were obviously decreased and PAI activity incre ased in the plasma of BSS model rabbits as compared with those of the normal rabbits (P 0.01 ). t_PA activi ty was decreased and PAI activity increased in the primary cultured supernatant of BSS model rabbits as compared with those of the normal rabbits (P 0.05 ). The differences of t_PA activity and PAI activity i n the subcultured supernatant of BSS model rabbits were not significa nt as compared with those of the normal rabbits (P 0.05 ). Conclusion Anticoagulant and fibrinolytic dysfunction p lays an imp ortant role in the occurrence and development of BSS." @default.
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- W2380703600 date "2001-01-01" @default.
- W2380703600 modified "2023-09-26" @default.
- W2380703600 title "Anticoagulant and Fibrinolytic Mechanism of VascularEndothelial Cells in Blood Stasis Syndrome" @default.
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