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- W2380729902 abstract "Objective To observe the effects of arsenic trioxide(As2O3)on the expressions of TNF-α,Fas and bcl-2 in lung adenocarcinoma cells(LAC)and to explore the mechanism of arsenic trioxide inducing apoptosis.Methods The expressions of TNF-α,Fas and bcl-2 in lung adenocarcinoma cells pretreated by arsenious acid were determined by the double antibody sandwich ABC-ELISA method.Results Compared with the control group,As2O3 showed no effects on the contents of bcl-2 in lung adenocarcinoma cells after 72 hours treatment,but increased the contents of TNF-α and Fas significantly,and the effects in different concentration groups had significant differences.The protein expressions of TNF-α and Fas showed a tendency of concentration-dependent increasing.Conclusions The results suggest that As2O3 induces the apoptosis of LAC cells possibly by up-regulating the expression of TNF-α and Fas." @default.
- W2380729902 created "2016-06-24" @default.
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- W2380729902 date "2007-01-01" @default.
- W2380729902 modified "2023-09-23" @default.
- W2380729902 title "Effects of Arsenic Trioxide on the Expressions of TNF-α,Fas and bcl-2 in Human Lung Adenocarcinoma Cells" @default.
- W2380729902 hasPublicationYear "2007" @default.
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