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- W2380739669 abstract "H NMR spectroscopy has been used to assess chronic toxicological effects of rare earth. Male Wistar rats have been administrated orally with La(NO-3)-3 at doses of 0.2,2.0,10 20mg/kg body weight for six months. The analysis for {}+1H NMR spectra of rats serum and rats urine after dosing rare earth was reported. The {}+1H NMR variation of numerous low %Mr% metabolites, including ketone bodies, lactate, glucose, urea, citrate and various amino acids, provided a sensitive measure of La+{3+} induced renal and liver damage and information on abnormal patterns of metablite excretion. The assay of some biochemical indexes in plasma supported NMR results. {}+1H NMR techniques could be applied to clinical diagnosis of abnormal metabolism of the inborn disease and the investigation of the toxicological effects of other drugs." @default.
- W2380739669 created "2016-06-24" @default.
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- W2380739669 date "2000-01-01" @default.
- W2380739669 modified "2023-09-25" @default.
- W2380739669 title "~1H NMR STUDIES OF BIOFLUIDS OF RATS ON LONG-TERM TOXICITY OF RARE EARTH" @default.
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