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- W2380751383 abstract "ObjectiveTo observe the effect of Salvia miltiorrhiza on cochlear stria vascularies in Cisplatin ototoxicity of guinea pig. MethodsEighteen guinea pigs were divided randomly into three groups. The normal control group, treated with physiological saline 2 ml/(kg·d) by I.P. for successively five days.The Cisplatin group, treated with Cisplatin 2 ml/(kg·d) by I.P. for successively five days. The Salvia miltiorrhiza group,treated with Salvia miltiorrhiza 8 ml/(kg·d) by I.M. from the first to seventhth day and Cisplatin 2 ml/(kg·d) by I.P. from the third to the seventh day. The general physiologic changes and auricle response were observed.The hearing threshold and cochlear blood flow were tested by electric response audiometry and laser Dopoler detector separately. The structure changes of stria vascularis were observed by using the metherd of stria vascularis flat. ResultsIn Salvia miltiorrhiza group the general physiological changes were better than that in Cisplatin group.Auricle response was sensitive except slow in 3 guinea pigs.Hearing threshold was ( 32.5 ± 7.5 )dB.Cochlear blood flow in bottom turn was 155.8 mV.Cochlear stria vascularis flat showed that expanded,capillaries and gathered RBC were observed occasionally.ConclusionSalvia miltiorrhiza has protective effects on Cisplatin ototoxicity by changes of stria vascularis." @default.
- W2380751383 created "2016-06-24" @default.
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- W2380751383 date "2004-01-01" @default.
- W2380751383 modified "2023-09-25" @default.
- W2380751383 title "EFFECT OF SALVIA MILTIORRHIZA ON COCHLEAR STRIA VASCULARIS IN CISPLATIN OTOTOXICITY OF GUINEA PIGS" @default.
- W2380751383 hasPublicationYear "2004" @default.
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