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- W2380757279 abstract "OBJECTIVE To establish an HPLC method for determination of teicoplanin in serum.METHODS Chromatographic conditions included Hypersil C_ 18 colunm,acetonitrile -0.01 mol· L -1 NaH_ 2PO_ 4 (27∶73, pH was adjusted to 2.02 with H_ 3PO_ 4) as mobile phase. The detective wavelength was 240 nm and the flow rate was 1 mL·min -1. RESULTS Two ways were used to make the standard curve of teicoplanin which showed good linearty in the concentration range of 4～ 100 mg·L -1 (r= 0.999 3, 0.998 1), the limit of quantity determination was 4 mg·L -1,the average recovery was 100.40%, 104.81%,with RSD of 4.96%, 4.75%(n=5).CONCLUSION The method was found to be simple, sensitive and accurate, it could be used for determination the concertration of teicoplanin in serum for the research work of clinical pharmac okinetics." @default.
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- W2380757279 date "2005-01-01" @default.
- W2380757279 modified "2023-09-26" @default.
- W2380757279 title "Determination of teicoplanin in serum by HPLC" @default.
- W2380757279 hasPublicationYear "2005" @default.
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