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- W2380761353 abstract "Objective To examine the interaction between capacitative calcium entry and arachidonic acid activated calcium entry, which co exist in non excitable cells.Methods In human embryonic kidney cells (HEK293 cells), the intracellular Ca 2+ concentration ([Ca 2+ ] i) in response to thapsigargin and arachidonic acid were measured by using acetoxymethyl ester of Fura 2 (Fura 2/AM).Results Both thapsigargin and arachidonic acid produced Ca 2+ release from the same intracellular Ca 2+ stores and Ca 2+ entry from extracellular space. These two Ca 2+ entry pathways exhibited mutual antagonism. The inhibition did not appear to result from a direct action of thapsigargin, from inhibition of SERCA pumps or depletion of Ca 2+ stores, or from entry of Ca 2+ through capacitative calcium entry channels.Conclusion It appeared that a discrete step in the pathway signaling capacitative calcium entry interacted with and inhibited the arachidonic acid pathway. The occurrence of mutual antagonism between the two distinct calcium entry pathways may provide protection for the cell against toxic Ca 2+ overload." @default.
- W2380761353 created "2016-06-24" @default.
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- W2380761353 date "2001-01-01" @default.
- W2380761353 modified "2023-09-25" @default.
- W2380761353 title "Interaction of Ca~(2+) entries between capacitative-mediated and arachidonic acid-mediated pathways" @default.
- W2380761353 hasPublicationYear "2001" @default.
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