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- W2380761777 abstract "Objective:To evaluate the effects of the triple therapy with rabeprazole + amoxicillin+tinidazole in the treatment of duodenal ulcer.Methods:145 patients with duodenal ulcer, who were positive for Helicobacter pylori(Hp), were randomly assigned to one of two treatment groups: 10 mg of rabeprazole twice daily for 1 week and subsequently triple regimens with 10 mg of rabeprazole once daily for 3 weeks plus amoxicillin (1 g) and tinidazole (0.5 g) twice daily for 1 week(n=75) or the adjunctive therapy of 20 mg of famotidine twice daily for 5 weeks to amoxicillin (1 g) and tinidazole (0.5 g) twice daily for 2 week (n=70). The cure rate of duodenal ulcer and Hp eradication rate post medications were designed to be the key efficacious measures, and improvement of the clinical symptoms as the secondary measures. Results: The patients received rabeprazole and famotidine experienced the complete cure rate of 96% and 81.4%(P0.01), and the Hp eradication rate of 90.7% and 71.4%(P0.01).73 out of 75 (97.3%) had complete improvement of the clinical symptoms, which showed a significant difference from the famotidine group (P0.01). No significant adverse events were reported.Conclusion:The adjunctive therapy of rabeprazole with antibiotics could cure duodenal ulcer and rapidly relieve the abdominal pain by the eradication of Hp." @default.
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- W2380761777 date "2005-01-01" @default.
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- W2380761777 title "Efficacy of rabeprazole for the treatment of duodenal ulcer" @default.
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