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- W2380772389 abstract "To observe the dynamic changes of the plasma ET-1 and the effect of low dose nitroglycerin in patients with coronary artery bypass surgery.40 patients with coronary artery bypass surgery were divided into group A and B. Group B received intravenous nitroglycerin 1 microg x kg(-1) x min(-1) perioperatively. We used RIA to assay the plasma ET-1 level. All the hemodynamic parameters were recorded by the Swan-Ganz catheter.The preoperative plasma ET-1 level in patients with coronary artery disease was significantly higher than the normal level. Five minutes after cardiopulmonary bypass in these patients the plasma ET-1 level was increased significantly until 6 to 8 hours after operation. The increased plasma ET-1 level in group B was less than in group A. There was a positive correlation between the plasma ET-1 level and the mean pulmonary pressure in group A 2 and 8 hours after operation.In patients undergoing coronary artery bypass surgery, the increased plasma ET-1 level may be partly due to the influence of cardiopulmonary bypass. Low dose of nitroglycerin is beneficial to these patients." @default.
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- W2380772389 date "2000-09-01" @default.
- W2380772389 modified "2023-10-18" @default.
- W2380772389 title "[Perioperative changes of plasma ET-1 in patients undergoing coronary artery bypass grafting and the effect of nitroglycerin]." @default.
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