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- W2380778567 abstract "Objective: To study the effects of Bunao Zhixian powder on the expression of GABA and GABAα in the brain of Pentylenetetrazole( PTZ)- kindled chronic epileptic rats. Methods: 60 SD rats were randomly divided into six groups,control group,epileptic rat model group,Sodium valproate group,low dose of Bunao Zhixian powder therapy group,middle dose of Bunao Zhixian powder therapy group and high dose of Bunao Zhixian powder therapy group. Rat kindling model with epilepsy was established by PTZ- injection. By immunohisto chemistry method detect the protein expression of GABA and GABAα in hippocampus of rats. Results:The occurrence and seizure level were evaluated by using Racine method. The rats with Ⅲ to V seizure level were chosen for the following studies. The expression of GABA and GABAα increased significantly between the Sodium valproate group and the high dose of Bunao Zhixian powder therapy group. There were significant differences by comparing with model group( P 0. 05). Conclusion: Bunao Zhixian powder plays a significantly increased role in excitatory neurotransmitter and receptor,so as to protect the brain tissue,to alleviate the symptoms of epilepsy and to reduce the role of the damage caused by epilepsy." @default.
- W2380778567 created "2016-06-24" @default.
- W2380778567 creator A5003596230 @default.
- W2380778567 date "2013-01-01" @default.
- W2380778567 modified "2023-09-23" @default.
- W2380778567 title "Effect of Bunao Zhixian Powder on the Expression of GABA and GABAα of PTZ- kindled Chronic Epileptic Rats" @default.
- W2380778567 hasPublicationYear "2013" @default.
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