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- W2380778811 abstract "Objective:To investigate the mechanism of human hepatocellular carcinoma HepG2 cells proliferation induced by DAMPs.Methods:HepG2 cells were divided into four groups:control group,DAMPs group,IL-6 siRNA group,and IL-6 siRNA+DAMPs group.MTT assay was applied to investigate the proliferation of HepG2 cells.Expression of IL-6and STAT3 mRNA in HepG2 cells was measured by quantitative RT-PCR,and the protein expression level of STAT3 and p-STAT3was detected by Western blotting.Results:MTT assay demonstrated that the proliferation of HepG2 cells was enhanced when exposed to DAMPs(P0.01,vs.control).The result of quantitative RT-PCR showed that the expression of IL-6 mRNA and STAT3 mRNA increased markedly when exposed to DAMPs(P0.01,vs.control).The protein expression level of STAT3among the four groups have no differences,but the p-STAT3 in DAMPs group were higher than in control group(P0.01).Conclusion:DAMPs may promote the proliferation of HepG2 cell by IL-6/STAT3 signaling pathway." @default.
- W2380778811 created "2016-06-24" @default.
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- W2380778811 date "2013-01-01" @default.
- W2380778811 modified "2023-09-27" @default.
- W2380778811 title "Mechanism of the Effect of DAMPs on Human Hepatocellular Carcinoma HepG2 Cells" @default.
- W2380778811 hasPublicationYear "2013" @default.
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