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- W2380783417 abstract "Background and Objective:Data from pharmacokinetic and pharmacodynamic studies indicate that the adverse interaction between antiplatelet drugs,especially clopidogrel,and proton pump inhibitor(PPI) may vary among PPIs.We aimed to evaluate systematically whether individual PPIs differ in their risk for cardiovascular events when concomitantly administered with antiplatelet drugs.Methods:Such databases as the Cochrane Library,PubMed、EMbase、Elsevier and Web of science were searched during January 2010 through September 2012.The bibliographies of the retrieved articles were also checked.The RevMan 5.0 soft ware was used for meta-analyses.Results:A total of 14 studies with 67131 participants were included.The results of meta-analyses showed that:1) the use of antiplatelet drugs combined with omeprazole was associated with increasing the risk of cardiovascular events;2) the use of antiplatelet drugs combined with rabeprazole was associated with increasing the risk of cardiovascular events;3)There was no enough evidence to reach the conclusion that the combination use with lansoprazole could increase the risk of cardiovascular events;4)the use of antiplatelet drugs combined with esomeprazole wasn't associated with the increasing risk of cardiovascular events;5) the use of antiplatelet drugs combined with pantoprazole wasn't associated with increasing the risk of cardiovascular events.Conclusion:Omeprazole or Rabeprazole combined with antiplatelet drugs may increase the risk of incident cardiovascular events.However,Pantoprazole,Esomeprazole and Lansoprazole does not increase the risk of incident cardiovascular events when combined with antiplatelet drugs." @default.
- W2380783417 created "2016-06-24" @default.
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- W2380783417 date "2013-01-01" @default.
- W2380783417 modified "2023-09-28" @default.
- W2380783417 title "Safety of antiplatelet drugs-proton pump inhibitors combination therapy in cardiovascular events:a systematic review" @default.
- W2380783417 hasPublicationYear "2013" @default.
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