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- W2380792502 abstract "Objective To evaluate the effect of papain hydrolysates originated from sheep bone on the immunity of healthy mice.Methods ICR mice were divided by body mass into control (0 g/kg),low-dose (0.5 g/kg),mediumdose (1.0 g/kg) and high-dose (3.0 g/kg) groups.Carbon clearance test and quantitative SRBC hemolysis test were used to determine the impact of the hydrolysates on mice innate immunity and humoral immunity,respectively,and MTT assay was used to determine the effect of low (0.01 mg /mL),medium (0.1 mg /mL),high (1 mg /mL) concentration of the hydrolysates on the cell-mediated immunity (CMI).Results Only the hydrolysate of medium dose group significantly enhanced the phagocytic capacity of macrophages.The amounts of antibodies produced by splenic cells of all dosage groups were markedly higher than that of the control group,while antibodies produced by high-dose group were significantly lower than the other two groups.Supplementation of different concentrations of hydrolysates significantly enhanced lymphocyte proliferation in response to ConA stimulation in vitro,but high concentration was not as good as low and medium concentration.Conclusions Sheep bone collagen papain hydrolysates has a potential to enhance both the specific and innate immunity of normal mice,but this kind of immunomodulatory activity shows no linear relationship with the dosage administrated." @default.
- W2380792502 created "2016-06-24" @default.
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- W2380792502 date "2010-01-01" @default.
- W2380792502 modified "2023-09-24" @default.
- W2380792502 title "Immunomodulatory Effect of Papain Hydrolysate Originated from Sheep Bone on Mice" @default.
- W2380792502 hasPublicationYear "2010" @default.
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