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- W2380806384 abstract "Aim To investigate anticancer effect and potential mechanism of tanshinone Ⅱ A(Tan Ⅱ A) onhuman lung adenocarcinoma cell line A549 cells.Methods Antiproliferative effect of Tan ⅡA on A549 cells was evaluated by morphological examination and MTT assay.Apoptosis detection was carried out using Hoechest33258 and PI double-dyeing method.Intracellular Ca2+ concentration and mitochondria membrane potential were detected by fluorospectrophotometer.Bad and MT-1A transcript analysis were carried by realtime reverse transcriptase-polymerase chain reaction (RT-PCR).Results Tan ⅡA could inhibit proliferation of A549 cells in dose-and time-dependent manner.50% inhibiting concentration of Tan Ⅱ A on A549 cells in 24,48,and 72h was 117.85,14.87 and 6.89μmol·L-1 respectively.Typical apoptotic morphology such as chromatin aggregation was observed,and apoptotic inducing effect of Tan ⅡA on A549 cells for 24h was in a dose-dependent manner.After treated with Tan ⅡA,intracellular Ca2+ concentration of A549 cells was increased,mitochondria membrane potential of the cells was decreased,relative Bad mRNA level of the cells was up-regulated and that of MT-1A was down-regulated.Conclusion Tan Ⅱ Ahas anticancer effect on A549 cells through apoptosis via calcineurin-dependent pathway and MT-1A downregulation." @default.
- W2380806384 created "2016-06-24" @default.
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- W2380806384 date "2010-01-01" @default.
- W2380806384 modified "2023-09-27" @default.
- W2380806384 title "Apoptosis inducing effect of Tanshinone IIA onhuman lung adenocarcinoma A549 cells" @default.
- W2380806384 hasPublicationYear "2010" @default.
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