Matches in SemOpenAlex for { <https://semopenalex.org/work/W2380807696> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W2380807696 abstract "AIM To study anti- tumor effects of paclitaxel micelle(PTX- PM) for injection on tumorbearing mice in vivo. METHODS Male nude mice were implanted with xenograft fragments of human lung adenocarcinoma A549 or human colorectal cancer HT29 tissue subcutaneously in the right flank. When tumor in the nude mice reached a tumor volume of 100 mm3, the nude mice bearing tumor were divided into 6 groups(control, polymeric micelle(PM), paclitaxel injection(PTXI), three PTX- PM treated groups). Each group had 6 mice. A single dose of PTX- PM in saline was administered intravenously at 10, 20 mg·kg-1every three days. PTXI in saline was also administered intravenously at 20 mg·kg-1every three days, 7- 8 times in the experiment. While in the PTX- PM 50 mg·kg-1group only 4 times were given. In control experiments, saline and PM vehicle were used. Tumor size and body weight was measured before every time for the duration of the study,and tumor volume, relative tumor volume or relative proliferation rate of tumor was calculated. RESULTS None of the animals treated with PTX- PM died in the two model experiments during the experimental period. Only the tumor- bearing mice in the PTX- PM 50 mg·kg-1group appeared response slowing, activity decreasing, poor skin luster, loose stools and body weight losing(P 0.05 or P 0.01) after administered 4 times. There were no obviously abnormal reactions in the mice of the 10 or 20 mg·kg-1group. In the PTX- PM 20 or 50 mg·kg-1group of the two model experiments, the relative tumor proliferation rates were less than 40% and the relative tumor volumes were significant different from the control group till the end of the experiment. While in the PTX- PM10 mg·kg-1group or PM group the relative tumor proliferation rates were greater than 40% and the relative tumor volumes were similar to the control group. CONCLUSION Under the experimental conditions, PTX- PM 20 or50 mg·kg-1could inhibit HT29 and A549 xenografts growth in nude mice, and had a significant anti- tumor effect, but the systematic toxicity of PTX- PM 50 mg·kg-1dose was significantly higher than 20 mg·kg-1." @default.
- W2380807696 created "2016-06-24" @default.
- W2380807696 creator A5041055222 @default.
- W2380807696 date "2014-01-01" @default.
- W2380807696 modified "2023-09-25" @default.
- W2380807696 title "Anti-tumor effects of paclitaxel micelle for injection in vivo" @default.
- W2380807696 hasPublicationYear "2014" @default.
- W2380807696 type Work @default.
- W2380807696 sameAs 2380807696 @default.
- W2380807696 citedByCount "0" @default.
- W2380807696 crossrefType "journal-article" @default.
- W2380807696 hasAuthorship W2380807696A5041055222 @default.
- W2380807696 hasConcept C121608353 @default.
- W2380807696 hasConcept C126322002 @default.
- W2380807696 hasConcept C134018914 @default.
- W2380807696 hasConcept C147583825 @default.
- W2380807696 hasConcept C150903083 @default.
- W2380807696 hasConcept C185592680 @default.
- W2380807696 hasConcept C207001950 @default.
- W2380807696 hasConcept C2776694085 @default.
- W2380807696 hasConcept C2777292972 @default.
- W2380807696 hasConcept C2777397205 @default.
- W2380807696 hasConcept C2781182431 @default.
- W2380807696 hasConcept C71924100 @default.
- W2380807696 hasConcept C86803240 @default.
- W2380807696 hasConcept C98274493 @default.
- W2380807696 hasConceptScore W2380807696C121608353 @default.
- W2380807696 hasConceptScore W2380807696C126322002 @default.
- W2380807696 hasConceptScore W2380807696C134018914 @default.
- W2380807696 hasConceptScore W2380807696C147583825 @default.
- W2380807696 hasConceptScore W2380807696C150903083 @default.
- W2380807696 hasConceptScore W2380807696C185592680 @default.
- W2380807696 hasConceptScore W2380807696C207001950 @default.
- W2380807696 hasConceptScore W2380807696C2776694085 @default.
- W2380807696 hasConceptScore W2380807696C2777292972 @default.
- W2380807696 hasConceptScore W2380807696C2777397205 @default.
- W2380807696 hasConceptScore W2380807696C2781182431 @default.
- W2380807696 hasConceptScore W2380807696C71924100 @default.
- W2380807696 hasConceptScore W2380807696C86803240 @default.
- W2380807696 hasConceptScore W2380807696C98274493 @default.
- W2380807696 hasLocation W23808076961 @default.
- W2380807696 hasOpenAccess W2380807696 @default.
- W2380807696 hasPrimaryLocation W23808076961 @default.
- W2380807696 hasRelatedWork W1443108546 @default.
- W2380807696 hasRelatedWork W1868006138 @default.
- W2380807696 hasRelatedWork W2008187359 @default.
- W2380807696 hasRelatedWork W2060063916 @default.
- W2380807696 hasRelatedWork W2352517069 @default.
- W2380807696 hasRelatedWork W2354189070 @default.
- W2380807696 hasRelatedWork W2362923964 @default.
- W2380807696 hasRelatedWork W2366271449 @default.
- W2380807696 hasRelatedWork W2369183795 @default.
- W2380807696 hasRelatedWork W2372472785 @default.
- W2380807696 hasRelatedWork W2377225125 @default.
- W2380807696 hasRelatedWork W2387930885 @default.
- W2380807696 hasRelatedWork W2388762021 @default.
- W2380807696 hasRelatedWork W2389789178 @default.
- W2380807696 hasRelatedWork W2390044649 @default.
- W2380807696 hasRelatedWork W2392685597 @default.
- W2380807696 hasRelatedWork W2545657964 @default.
- W2380807696 hasRelatedWork W2784043644 @default.
- W2380807696 hasRelatedWork W3028799211 @default.
- W2380807696 hasRelatedWork W3030345644 @default.
- W2380807696 isParatext "false" @default.
- W2380807696 isRetracted "false" @default.
- W2380807696 magId "2380807696" @default.
- W2380807696 workType "article" @default.