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- W2380816504 abstract "Objective To study the role of P-selectin in microvascular inflammtory damage after cerebral ischemia -reperfusion. Methods The rats were randomly divided into the groups as sham operated control group and ischemia-reperfusion 1 h, 3 h, 6 h, 12 h,24 h, 48 h, 72 h groups. The global cerebral ischemia-reperfusion model was formed by occluding three arteries. The expression of laminin was evaluated by immunohistochemical methold, and IL-8 mRNA was detected by in situ hybridization. Results The expression of IL-8 mRNA was increased as early as 1 h after reperfusion and peaked at 24 h after reperfusion. At 72 h after reperfusion, it was still higher than that of sham operated control group. The expression of laminin was strong positive in sham operated control group.At 3 h after reperfusion, the expression of laminin began to decrease, and its lowest level was during 24-48 h. At 72 h, the expression began to reappear. Conclusions The microvascular inflammatory damage appeared in early period after cerebral ischemia-reperfusion. IL-8 was involved in the inflammatory damage of endothelial cell during global cerebral ischmia-reperfusion." @default.
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- W2380816504 date "2004-01-01" @default.
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- W2380816504 title "Experimental Study of IL-8 and Microvascular Inflammatory Damage after Cerebral Ischemia-reperfusion" @default.
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