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- W2380821130 abstract "Objective To observe the effects of Qingdai(Indigo Naturalis) and Indimbin,an active ingredient of Indigo Naturalis on the expression of Foxp3,a key marker of CD4CD25 regulatory T cells,in the mice ulcerative colitis(UC),in an attempt to study their action mechanisms and targets.Methods Fifty BABL/c nice were randomized into five groups:normal group,model group,Indirubin group,Qingdai group and 5-ASA Group.The mice except for those in the normal group were given 5%dextran sulfate sodium(DSS) for5 days to establish UC model.From the fifth day,corresponding treatments were applied to these groups for total seven clays.The general conditions,the histological appearance of the colon and the change of Foxp3 expression were observed.Results Significant reduction of Foxp3 expression was found in the model group compared with the normal group(P0.01),and Foxp3 expressions were significantly increased in all treatment groups while compared with the model group(P0.01).Conclusion Qingdai(Indigo Naturalis) and Indirubin can upregulate expression of Foxp3 of CD4CD25 regulatory T cells to manage ulcerative colitis." @default.
- W2380821130 created "2016-06-24" @default.
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- W2380821130 date "2011-01-01" @default.
- W2380821130 modified "2023-09-26" @default.
- W2380821130 title "Influence of Indirubin on Foxp3 expression of CD4CD25 regulatory T cells in ulcerative colitis mice" @default.
- W2380821130 hasPublicationYear "2011" @default.
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