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- W2380821773 abstract "The purpose was to observe the effects of ibutilide on canine electrophysiological characters, and further more, to explore the mechanism of ibutilide′s converting atrial flutter(AFL). 15 mongrel dogs were anesthetized and intubated with a tracheal tube. The heart was exposed through a thoracotomy and then electrodes were fixed by suture. The electrophysiologic variables were measured with and without ibutilide(for the 10-minute infusions the dose was 0.10mg/kg, and 30 minutes later, the maintaining dose was 0.01mg/min). These variables included the heart rate, the conduction of intraatrium and interatrium, the conduction ratio of isthmus, the effective refractory period, and so on. Results:Ibutilide had the significant suppressing effect for the sinus atrial node. The peak response time was 20~30 min and the heart rate recovered without drug administration. The atrial, ventricular and pulmonary vein effective refractory period were significantly prolonged(P0.05~0.001).However, there were no significant difference on the conduction of intraatrium, interatrium and isthmus(P0.05). Conclusion:The mechanism of ibutilide′s rapidly terminating AFL is speculated on the prolongation of the refractory period which could cause the whole excitable gap of the reentrant circuit to be affected by refractoriness, thus to terminate the AFL due to the reentrant wavefront′s inability to proceed." @default.
- W2380821773 created "2016-06-24" @default.
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- W2380821773 date "2005-01-01" @default.
- W2380821773 modified "2023-09-23" @default.
- W2380821773 title "The Effects of Ibutilide on Canine Electrophysiological Characters" @default.
- W2380821773 hasPublicationYear "2005" @default.
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