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• W2380833360 abstract "Objective To investigate the protective effect of exogenous insulin-like growth factor-1(IGF-1) on the gut barrier function dysfunction induced by severe acute pancreatitis(SAP) and its possible mechanism.Methods 72 male Wistar rats were randomly divided into 3 equal groups:SAP group(SAP) undergoing retrograde infusion of 5.0 % sodium taurocholate so as to establish SAP models,IGF-1 treatment group,undergoing subcutaneous injection of IGF-1 30 min before and 3 h after the operation,and sham operation(SO) group,undergoing retrograde infusion of normal saline.6,12,and 24 hours later 8 rats in each group were killed with the blood samples taken from the right ventricles to detect the serum amylase,endotoxin,and diamine oxydase(DAO) .Specimens of small intestine were obtained to undergo pathological examination.TUNEL method was used to observe the apoptosis of mucosal cells.Results The serum amylase levels of the SAP group at different time points were all significantly higher than those of the SO group(all P 0.05) .,and the IGF-1 group was not significantly different from that of the SAP group(P 0.05) 6 h after operation,but significantly lower than that of the SAP group 12 h and 24 h after the operation(both P 0.05) ;however,the serum amylase levels of the IGF-1 group at different time points were not significantly different from those of the SO group(all P 0.05) .The serum endotoxin levels 12 h and 24 h after operation of the SAP group were both significantly higher than those of the SO group(both P 0.01) ,and 12 h after operation of the IGF-1 group was significantly lower than that of the SAP group(P 0.01) .The pathological scores of the small intestine at different time points of the SAP group were all significantly higher than those of the SO group(all P 0.05) ,and the IGF-1 group were all significantly lower than those of the SAP group(all P 0.05) .The apoptotic indexes at different time points of the SAP group were all significantly higher than those of the SO group(all P 0.01) ,and the IGF-1 group were all significantly lower than those of the SAP group(all P 0.01) ,but not significantly different from those of the SO group(all P 0.05) .Conclusion Exogenous IGF-1 alleviates SAP-induced injury to intestinal mucosal and endotoxemia.The mechanism may be that IGF-1 inhabits excessive apoptosis of the intestinal mucosal." @default.
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• W2380833360 date "2008-01-01" @default.
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• W2380833360 title "Protective effect of exogenous insulin-like growth factor-1 on gut barrier function of severe acute pancreatitis:experiment with rats" @default.
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