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- W2380833934 abstract "Objective To study the release profile in GCF of minocycline from Periocline dental ointment in auxiliary treatment of severe chronic periodontitis.Methods Patients with severe periodontitis from our periodontal department were recruited for the study.After an initial therapy,20 periodontal sites,PD6 mm,were selected for applying 0.05 ml 2% minocycline-HCl ointment in periodontal pocket.GCF samples were collected using filter paper strip before and after oinment placement at different times.The minocycline-HCl were eluted from paper strip and quantified by HPLC.The concentration of minocycline-HCl in GCF was calculated.Results The correlation between drug concentration of minocycline-HCl and peak area is in positive linear correlation by HPLC analysis.The concentration of minocycline-HCl in periodontal pocket can maintain 1 μg/ml for more than 5 days.Conclusions The study determined the minocycline release profile of the Periocline dental ointment in the GCF.The effective drug concentration in the periodontal pocket can maintain long duration which shows the ointment is a sustained drug delivery system." @default.
- W2380833934 created "2016-06-24" @default.
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- W2380833934 date "2005-01-01" @default.
- W2380833934 modified "2023-09-28" @default.
- W2380833934 title "In vivo study of 2% minocycline-HCl ointment release profile in gingival crevicular fluid" @default.
- W2380833934 hasPublicationYear "2005" @default.
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