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- W2380840222 abstract "Objective:To investigate the antinociceptive effects of Melatonin(Mel)on pain in post-injury rats and to explore the possible site of the analgesic action of Mel.Method:Rat trauma pain model was established in Wis-tar rats by limb amputation with the determination of tail-flick latency to ho t water at50℃.The animals were in-traperitoneally(i.p.)injected Mel(30,60,120m g/kg),pethidine(Pt,20mg/kg),Mel+Pt(10+10mg/kg)and solvent respe ctively at0min, 1d,2d,3d post-injury.The pain thresholds were measured at20min,40min,80min,120mi n after the drugs used at3d.In addition,the pain thresholds were also measured a t20min,40min,80min,120min after i.c.v Mel(0.25?0.5?1.0mg/kg)one time at3d in i njuried rats.Result:The pain thresholds reached to the lowest point at3d post-in jury,and then returned to the normal level at7d post-injury.Both i.p.Mel(30-120 mg/kg)or i.c.v.Mel(0.25-1.0mg/kg)can increase the pain thresholds in injuried r ats in a dose-dependent manner,and the analgesic effects of which reached to cli max at40min and lasted until120min after Mel used.Coadministration of Mel(10mg/k g)with Pt(10mg/kg)can also enhance the pain thresholds obviously.Conclusion :Mel has obvious antinociceptive effect on pain in post-injury rats,and the central n ervous system(CNS)may be the primary site for Mel to elicit the re-sponse.Moreo ver,there is a marked synergistic effect between Mel and Pt." @default.
- W2380840222 created "2016-06-24" @default.
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- W2380840222 date "2003-01-01" @default.
- W2380840222 modified "2023-09-26" @default.
- W2380840222 title "A research on the effects of melatonin on post-injury pain and its possible action site" @default.
- W2380840222 hasPublicationYear "2003" @default.
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