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- W2380843479 abstract "Objectives To investigate pharmacokinetics of pseudoephedrine and chlorpheniramine maleate in dogs and establish a method for the simultaneous determination of plasma pseudophedrine and chlorpheniramine maleate.Methods 8 Beagle dogs were orally administered a single dose of pseudoephedrine hydrochloride and chlorpheniramine maleate osmotic pump(2tablets).The plasma concentrations were determined by LC-MS.The pharmacokinetics parameters of the two drugs of the test preparation were caculated.Results The pharmacokinetics parameters of pseudophedrine and chlorpheniramine maleate were as follows:t_(1/2)(3.36±1.05) h and(5.01±2.91) h;t_(max)(5.75±1.49) h and(4.06±1.70) h;ρ_(max)(1110.86±200.61) μg·L~(-1) and(5.02±1.81) μg·L~(-1);AUC_(0-t)(10 755.43±3274.35) μg·h·L~(-1) and(34.71±(22.15)) μg·h·L~(-1).Conclusions This method is simple,rapid,sensitive and accurate and can be used for investigating the pharmacokinetics of pseudophedrine hydrochloride and chlorpheniramine maleate osmotic pump." @default.
- W2380843479 created "2016-06-24" @default.
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- W2380843479 date "2006-01-01" @default.
- W2380843479 modified "2023-09-25" @default.
- W2380843479 title "Pharmacokinetics of pseudophedrine and chlorpheniramine maleate osmotic pump" @default.
- W2380843479 hasPublicationYear "2006" @default.
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