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- W2380845207 abstract "Objective To investigate the significance of MMP-9 and TIMP-1 test for assessing the occurrence and development of chronic heart failure.Methods One hundred and twenty-seven patients with chronic heart failure were enrolled in the observation group,and 40 cases community health people were selected for the control group. The levels of serum MMP-9 and TIMP-1 were detected and the LVEF and E/E ' were evaluated using endocardiography. Results Compared with the control group, the level of MMP-9 was significantly higher(P 0.01) but the level of TIMP-1 had significantly decreased(P0.05) in the observation group. And the ratio of MMP-9 and TIMP-1 had significantly increased compared with the control group(P 0.05). There were statistically significant differences of LVEF and E/E' between the observation group and control group(P 0.05). In the observation group,the level of MMP-9, MMP-9/TIMP-1,LVEF and E/E' were increased but the level of TIMP-1 decreased significantly in cases with cardiac functional class III compared with cardiac function class II(P 0.05). There were significant differences between the cases with class IV heart function and class II,III in the levels of MMP-9,TIMP-1 and MMP-9/TIMP-1(P 0.05). In the cases of class IV heart function,the LVEF and E/E' have significantly increased compared with the cases of class II(P 0.05). MMP-9 + TIMP-1 + MMP-9/TIMP-1 combination has higher sensitivity and specificity than the MMP-9,TIMP-1 and MMP-9/TIMP-1 single indicator, and the joint diagnostic value of LVEF + E/E' was less than that of IL-18+ NT-ProBNP. Conclusion The levels of MMP-9 and TIMP-1 and their ratio may have contributed to the early detection and diagnosis for chronic heart failure,and help to determine the disease progression." @default.
- W2380845207 created "2016-06-24" @default.
- W2380845207 creator A5056037038 @default.
- W2380845207 date "2013-01-01" @default.
- W2380845207 modified "2023-09-25" @default.
- W2380845207 title "Assessment of Cardiac Remodeling in Patients with Chronic Heart Failure Condition and the Clinical Significance" @default.
- W2380845207 hasPublicationYear "2013" @default.
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