Matches in SemOpenAlex for { <https://semopenalex.org/work/W2380847597> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2380847597 abstract "Objective To investigate the release behavior of paclitaxel under proteinase K after liposomal paclitaxel in PLGA-PEG-PLGA hydro-gel was prepared.Methods Liposomal paclitaxel was prepared by dry film-hydration method and PLGA-PEG-PLGA polymer with mass ratio of 1∶ 2∶ 1 was synthesized.Drug-loaded liposomes were mixed in polymer hydro-gel and scanning electron microscope and laser particle detector were used respectively to observe the morphology and to determine the particle-sizes.High performance liquid chromatography was used to determine the release profile of paclitaxel under proteinase K.Results Paclitaxel-loaded liposomes were evenly distributed in hydro-gel,and paclitaxel exhibited 0-order release behavior.Proteinase K in release medium could accelerate the release speed of paclitaxel.The amounts of liposomes entrapped in hydro-gels had little effect on the release behavior and speed of paclitaxel.The amount of entrapped paclitaxel in liposomes had no obvious effect on the release behavior and speed of itself.As the particle-diameters of liposomes increased,paclitaxel release speed and release amount after 1 week were a little lower than those with smaller diameters.All samples released thoroughly by and large after 1 week.Conclusions Situ,0-order and sustained release of paclitaxel can be realized by being loaded into liposomes which are further loaded in biodegradable polyester hydro-gel.Proteinase K in release medium can accelerate their release speed without affecting release behavior." @default.
- W2380847597 created "2016-06-24" @default.
- W2380847597 creator A5035817377 @default.
- W2380847597 date "2013-01-01" @default.
- W2380847597 modified "2023-09-26" @default.
- W2380847597 title "Preparation of Paclitaxel Liposome in PLGA-PEG-PLGA Hydro-gel and Drug Release under Enzyme" @default.
- W2380847597 hasPublicationYear "2013" @default.
- W2380847597 type Work @default.
- W2380847597 sameAs 2380847597 @default.
- W2380847597 citedByCount "0" @default.
- W2380847597 crossrefType "journal-article" @default.
- W2380847597 hasAuthorship W2380847597A5035817377 @default.
- W2380847597 hasConcept C10138342 @default.
- W2380847597 hasConcept C141071460 @default.
- W2380847597 hasConcept C147789679 @default.
- W2380847597 hasConcept C162324750 @default.
- W2380847597 hasConcept C163588942 @default.
- W2380847597 hasConcept C171250308 @default.
- W2380847597 hasConcept C185154212 @default.
- W2380847597 hasConcept C185592680 @default.
- W2380847597 hasConcept C187530423 @default.
- W2380847597 hasConcept C192562407 @default.
- W2380847597 hasConcept C202751555 @default.
- W2380847597 hasConcept C2776694085 @default.
- W2380847597 hasConcept C2777292972 @default.
- W2380847597 hasConcept C2780165375 @default.
- W2380847597 hasConcept C43617362 @default.
- W2380847597 hasConcept C54400483 @default.
- W2380847597 hasConcept C55493867 @default.
- W2380847597 hasConcept C71924100 @default.
- W2380847597 hasConceptScore W2380847597C10138342 @default.
- W2380847597 hasConceptScore W2380847597C141071460 @default.
- W2380847597 hasConceptScore W2380847597C147789679 @default.
- W2380847597 hasConceptScore W2380847597C162324750 @default.
- W2380847597 hasConceptScore W2380847597C163588942 @default.
- W2380847597 hasConceptScore W2380847597C171250308 @default.
- W2380847597 hasConceptScore W2380847597C185154212 @default.
- W2380847597 hasConceptScore W2380847597C185592680 @default.
- W2380847597 hasConceptScore W2380847597C187530423 @default.
- W2380847597 hasConceptScore W2380847597C192562407 @default.
- W2380847597 hasConceptScore W2380847597C202751555 @default.
- W2380847597 hasConceptScore W2380847597C2776694085 @default.
- W2380847597 hasConceptScore W2380847597C2777292972 @default.
- W2380847597 hasConceptScore W2380847597C2780165375 @default.
- W2380847597 hasConceptScore W2380847597C43617362 @default.
- W2380847597 hasConceptScore W2380847597C54400483 @default.
- W2380847597 hasConceptScore W2380847597C55493867 @default.
- W2380847597 hasConceptScore W2380847597C71924100 @default.
- W2380847597 hasLocation W23808475971 @default.
- W2380847597 hasOpenAccess W2380847597 @default.
- W2380847597 hasPrimaryLocation W23808475971 @default.
- W2380847597 hasRelatedWork W1983032431 @default.
- W2380847597 hasRelatedWork W2001881925 @default.
- W2380847597 hasRelatedWork W2012996762 @default.
- W2380847597 hasRelatedWork W2018737989 @default.
- W2380847597 hasRelatedWork W2044558361 @default.
- W2380847597 hasRelatedWork W2073382628 @default.
- W2380847597 hasRelatedWork W2074181527 @default.
- W2380847597 hasRelatedWork W2079149632 @default.
- W2380847597 hasRelatedWork W2134694936 @default.
- W2380847597 hasRelatedWork W2168972911 @default.
- W2380847597 hasRelatedWork W2361673837 @default.
- W2380847597 hasRelatedWork W2363887619 @default.
- W2380847597 hasRelatedWork W2364280474 @default.
- W2380847597 hasRelatedWork W2369599645 @default.
- W2380847597 hasRelatedWork W2511004223 @default.
- W2380847597 hasRelatedWork W2862919414 @default.
- W2380847597 hasRelatedWork W2965952183 @default.
- W2380847597 hasRelatedWork W3080369286 @default.
- W2380847597 hasRelatedWork W3150994738 @default.
- W2380847597 hasRelatedWork W3162053772 @default.
- W2380847597 isParatext "false" @default.
- W2380847597 isRetracted "false" @default.
- W2380847597 magId "2380847597" @default.
- W2380847597 workType "article" @default.