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- W2380850498 abstract "Aim: To investigate the effect of dimethyl 4-(2-chlorophenyl )-1, 4-dihydro-2, 6-dimethyl-3, 5-pyridinedi-carboxylate (DCDDP), a dihydropyridine calcium antagonist, on superoxide dismutase (SOD) activity and malondialdehyde (MDA ) concentration in plasma and pulmonaryhomogenate in rat with pulmonary hypertension (PH ),mold of PH was Induced by a singal subcutaneous injectionof monocrotaline (MCT, 60 mg·kg-1). Methods: Threedoses (5, 50, 500 μp·kg-1 ) of DCDDP were injected by ip30 min before and once daily after MCT injection. Thechanges in SOD activity and MDA concentration were me-asured by colorimetric analysis, histopathologic changes inlung and pulmonary small arteries were observed withcolour image analysis system. Results: Four weeks after injection of MCT, the SOD activity in plasma (106 ± 45 NU·L-1 ) and pulmonary homogenate (317 ± 59 NU· L-1 ) weresignificant lower than that of control (155 ± 28, 505 ± 47 re-spectively P 0. 05 or P 0. 01 ). The MDA content inplasma (15±μmol· L-1 ) and pulmonary homogenate （59± 14 μmol·L-1 ) in MCT group were significant higherthan that of control (5. 3± 2. 9, 32 ± 19 μmol·L-1, P〈0' 05 or P 0. 01 ). DCDDP can effectively inhibit the de-crease in SOD activity, especially in middle dose (147 ±17,421 ± 54 NU·L-1) and low dose (173±29,406±73NU·L-1 P 0. 05,or P 0.01 )and prevent the MDA content increased by MCT in pulmonary homogenate (P 0.01 ).Conclusion: DCDDP can significantly inhibit the SOD activi-ty lowered and prevent the MDA content elevated by MCTin plasma and pulmonary homogenate. These may be relat-ed to its mechanism of NO elevated in Pulmonary ho-mogenate and treatment PH." @default.
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- W2380850498 date "1998-01-01" @default.
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- W2380850498 title "Effects of DCDDP, a dihydropyridine calcium antagonist, on SOD activity and MDA concentration in rat with pulmonary hypertension" @default.
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