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- W2380851907 abstract "OBJECTIVE To study the pharmacokinetic behavior of oleanolic acid self-microemulsifying drug delivery system(OA-SMEDDS)in rats.METHODS Concentrations of OA in rat plasma were determined by HPLC-MS.The plasma concentration-time profile of OA-SMEDDS was obtained and pharamcokinetic parameters were calculated using DAS ver 2.0with conventional tablet as reference.RESULTS The plasma concentration data of OA-SMEDDS and conventional tablet were both fitted to two-compartment model.The tmaxof OA-SMEDDS was decreased,while Cmaxand AUC were significantly increased,compared with reference tablet.CONCLUSION The self-microemulsifying drug delivery system significantly enhanced the absorption of OAin vivo and thus improved its bioavailability." @default.
- W2380851907 created "2016-06-24" @default.
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- W2380851907 date "2010-01-01" @default.
- W2380851907 modified "2023-09-25" @default.
- W2380851907 title "Pharmacokinetic study of oleanolic acid self-microemulsifying system in rat" @default.
- W2380851907 hasPublicationYear "2010" @default.
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