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- W2380855798 abstract "Objective To investigate if ulinastatin will protect the short-term postoperative cognitive function of elderly patients and influence the concentration of serum cytokines.Methods 60 elderly patients with hip replacement surgery were selected and received general anesthesia.Cognitive function was assessed 1 day preoperatively and 1 day postoperatively with MMSE.The concentration of serum S100βprotein was measured before anesthesia(T1),before extubation(T2),6 h(T3),24 h(T4) after surgery.The levels of serum TNF-α,IL-6 were measured 3 days after surgery.Results Compare to 1 day preoperatively,the postoperative MMSE score declined in both groups.In ulinastatin group,the score decreased in some degree,but in the control group was more significant(P0.05).In the T2~4,the concentration of serum S-100βwas higher than T1 after operation in control group.In the ulinastatin group,there was S-100βelevation in T3 and T4.Compare to control group,the concentration of S-100β was lower in any time point when after orthopedic operation.Three day after operation,the levels of serum TNF-α,IL-6 were higher than that before in both groups,but the elevate was more obviously in control group.Conclusion Ulinastatin has a protective effect upon short-term postoperative cognitive function in elderly patients with orthopedic surgery,and the effect may be related to inhibition of peripheral cytokine release." @default.
- W2380855798 created "2016-06-24" @default.
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- W2380855798 date "2011-01-01" @default.
- W2380855798 modified "2023-09-24" @default.
- W2380855798 title "Protective effect of Ulinastatin upon short-term postoperative cognitive function in elderly patients after orthopedic surgery" @default.
- W2380855798 hasPublicationYear "2011" @default.
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