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- W2380857529 abstract "Objective To observe the effects of melatonin on lung injury and NDRG2(N-myc downstream-regulated gene 2) expression after intestinal ischemia-reperfusion(I/R).Methods 40 healthy SD rats were randomly assigned to a sham group,an I/R group,a high-dose melatonin group(10 mg/kg),and a low-dose melatonin group(l mg/kg).The model of lung injury was established by superior mesenteric artery clamping/unclamping.30 minutes before clamping,melatonin was administered intraperitoneally to the rats in two melatonin groups,and normal saline in same volume was administered to the rats in the I/R group and the sham group.Then superior mesenteric arteries of the rats in the I/R group and two melatonin groups were clamped for 60 minutes.45 minutes after unclamping,right lung tissues were sampled for pathological examination and wet/dry(W/D) ratio measurement.The rats in the sham group underwent sham operation without clamping.The expression of NDRG2 protein in the lung tissue was detected by immunohistochemistry and Western-blot.Results Compared with the sham group,hemorrhage and inflammation of lung tissues were observed.The W/D was obviously increased and the NDRG2 expression was significantly decreased in the I/R group.Compared with the I/R group,mild hemorrhage and inflammation changes of lung tissues were observed and the W/D was decreased while the NDRG2 protein expression was increased significantly in two melatonin groups.There was no significant difference between two melatonin groups.Conclusion Melatonin may relieve lung injury after intestinal ischemia-reperfusion through up-regulating NDRG2 expression." @default.
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- W2380857529 date "2013-01-01" @default.
- W2380857529 modified "2023-09-24" @default.
- W2380857529 title "Effects of Melatonin on Lung Injury after Intestinal Ischemia-Reperfusion and NDRG2 Expression in Lung" @default.
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