Matches in SemOpenAlex for { <https://semopenalex.org/work/W2380882783> ?p ?o ?g. }
Showing items 1 to 63 of
63
with 100 items per page.
- W2380882783 abstract "AIM: To investigate the role of GATA-3 in the pathogenesis of airway inflammation in a Wistar rat asthma model.METHODS: The Wistar rat asthma model was made with conventional method and animals were divided into five groups(10 rats in each group): asthma group(A group),dexamethasone group(D group),antisense oligonucleotide group(AS group),nonsense oligonucleotide group(NS group) and normal control group(N group).Antisense,nonsense oligonucleotide were administered intranasally,and the dexamethasone was injected intraperitoneally.The airway inflammation was observed with HE staining method.The GATA-3 positive cells were stained immunohistochemically.The GATA-3 mRNA expression in pulmonary tissue was investigated with RT-PCR.The GATA-3 protein in pulmonary tissue was detected by Western blotting.RESULTS: In contrast to N group,the expression of GATA-3 mRNA, protein and the amount of inflammatory cells in pulmonary tissue in group A were increased significantly(P0.01) and were decreased evidently in group AS and D(P0.01).The expression of GATA-3 mRNA,protein and the amount of inflammatory cells in NS group were obviously increased compared with those in gropu AS and D(P0.01).The expression of GATA-3 was related to the amount of eosinophils(r=0.995).CONCLUSION: GATA-3 antisense oligonucleotide blocks the expression of GATA-3 gene and the infiltration of eosinophils.GATA-3 plays an important role in the effector phase of allergic airway inflammation in a Wistar rat asthma model." @default.
- W2380882783 created "2016-06-24" @default.
- W2380882783 creator A5003377806 @default.
- W2380882783 date "2006-01-01" @default.
- W2380882783 modified "2023-09-26" @default.
- W2380882783 title "Role of GATA-3 in the pathogenesis of airway inflammation in a rat asthma model" @default.
- W2380882783 hasPublicationYear "2006" @default.
- W2380882783 type Work @default.
- W2380882783 sameAs 2380882783 @default.
- W2380882783 citedByCount "0" @default.
- W2380882783 crossrefType "journal-article" @default.
- W2380882783 hasAuthorship W2380882783A5003377806 @default.
- W2380882783 hasConcept C104317684 @default.
- W2380882783 hasConcept C105580179 @default.
- W2380882783 hasConcept C126322002 @default.
- W2380882783 hasConcept C203014093 @default.
- W2380882783 hasConcept C204232928 @default.
- W2380882783 hasConcept C2776042228 @default.
- W2380882783 hasConcept C2776914184 @default.
- W2380882783 hasConcept C2780401358 @default.
- W2380882783 hasConcept C2780942790 @default.
- W2380882783 hasConcept C55493867 @default.
- W2380882783 hasConcept C71924100 @default.
- W2380882783 hasConcept C86803240 @default.
- W2380882783 hasConceptScore W2380882783C104317684 @default.
- W2380882783 hasConceptScore W2380882783C105580179 @default.
- W2380882783 hasConceptScore W2380882783C126322002 @default.
- W2380882783 hasConceptScore W2380882783C203014093 @default.
- W2380882783 hasConceptScore W2380882783C204232928 @default.
- W2380882783 hasConceptScore W2380882783C2776042228 @default.
- W2380882783 hasConceptScore W2380882783C2776914184 @default.
- W2380882783 hasConceptScore W2380882783C2780401358 @default.
- W2380882783 hasConceptScore W2380882783C2780942790 @default.
- W2380882783 hasConceptScore W2380882783C55493867 @default.
- W2380882783 hasConceptScore W2380882783C71924100 @default.
- W2380882783 hasConceptScore W2380882783C86803240 @default.
- W2380882783 hasLocation W23808827831 @default.
- W2380882783 hasOpenAccess W2380882783 @default.
- W2380882783 hasPrimaryLocation W23808827831 @default.
- W2380882783 hasRelatedWork W1578805809 @default.
- W2380882783 hasRelatedWork W1973786933 @default.
- W2380882783 hasRelatedWork W2171089276 @default.
- W2380882783 hasRelatedWork W2354360500 @default.
- W2380882783 hasRelatedWork W2359302797 @default.
- W2380882783 hasRelatedWork W2361458907 @default.
- W2380882783 hasRelatedWork W2363211101 @default.
- W2380882783 hasRelatedWork W2365082255 @default.
- W2380882783 hasRelatedWork W2366034077 @default.
- W2380882783 hasRelatedWork W2369793037 @default.
- W2380882783 hasRelatedWork W2370020682 @default.
- W2380882783 hasRelatedWork W2372080976 @default.
- W2380882783 hasRelatedWork W2377778893 @default.
- W2380882783 hasRelatedWork W2381608729 @default.
- W2380882783 hasRelatedWork W2385977148 @default.
- W2380882783 hasRelatedWork W2389440086 @default.
- W2380882783 hasRelatedWork W2390475863 @default.
- W2380882783 hasRelatedWork W2392302152 @default.
- W2380882783 hasRelatedWork W2393378308 @default.
- W2380882783 hasRelatedWork W3045737347 @default.
- W2380882783 isParatext "false" @default.
- W2380882783 isRetracted "false" @default.
- W2380882783 magId "2380882783" @default.
- W2380882783 workType "article" @default.