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- W2380885787 abstract "Objective To study the level and action of lipid peroxidation induced by manganese of different valence and dosage in SH SY5Y cells.Methods The SH SY5Y cells were incubated in culture with 0 25,0 50 and 0 75 mmol/L manganese for 24 hours respectively.The activities of SOD and GSH Px,the level of MDA,the ratio of GSH Px/MDA and the membrane fluidity were detected.Results Results showed that activities of SOD treated by Mn 2+ and Mn 3+ in low,media and high level respectively[(522 12±57 74),(498 38±37 29),(464 86±24 09),(499 79±30 86),(477 23±61 66),(435 95±74 04) NU/mg protein] were significantly lower than those in untreated cells(P0 01).The activities of GSH Px[(19 04±5 16),(17 74±5 91),(15 99±5 62),(16 58±6 19),(15 79±7 29),(14 23±5 20)U] were lower than those in untreated cells(P0 01), and GSH Px/MDA of the cell treated by Mn 3+ and Mn 2+ were lower than those of the untreated cells,while the MDA and the difference of the membrane fluidity increased greatly as compared to controls(P0 05).With the treatment in the same dose,the change in cells treated with Mn 3+ was more significant than that in cells treated with Mn 2+ .Conclusions Manganese could promote lipid peroxidation,and cause membrane fluidity to decrease.The toxicity effects of Mn 3+ are more powerful than that of Mn 2+ ." @default.
- W2380885787 created "2016-06-24" @default.
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- W2380885787 date "2004-01-01" @default.
- W2380885787 modified "2023-09-25" @default.
- W2380885787 title "Lipid Peroxidation Actions of Manganese of Different Valence in SH-SY5Y Cells" @default.
- W2380885787 hasPublicationYear "2004" @default.
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