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- W2380887200 abstract "OBJECTIVE: To evaluate the efficacy and the delayed and long time effect of indapainide 1.5mg sustained-release with mild to moderate essential hypertension. Methods: According WHO/ISH, 30 patients with mild to moderate essential hypertension were studied, twelve was male, and eighteen was female. A 2-week placebo washout period was followed by an 8-week open treatment period of indapamide 1.5mg sustained-release. At the end of placebo mn-in and 2,4,6,8 weeks after treatment, systolic blood pressure, diastolic blood pressure and heart rate were measured. At the end of placebo run-in and 8 weeks after treatment, 30-hour ambulatory blood pressure monitoring were recorded. Results: After 8-weeks open treatment, mean sitting systolic blood pressure(SBP)/ diastolic blood pressure(DBP) decreased significantly (23.4 ±15.5/9.5 ±7.7)mmHg, P 0.001 .The significant antihypertensive effect was seen after 2 weeks of therapy and continued throughout the 8 weeks. In the 30-hour ambulatory blood pressure monitoring with treatment before ,mean SBP/DBP; 24-hour and 25-30-hour all reduced significantly compared with baseline values,( 13.2/6.4 nimHg and 12. 1/5.0 mmHg). Conclusion: Indapamide 1.5mg sustained-release is effective antihypertensive with diuretic and vasodilating activity on mild to moderate essential hypertension. Blood pressure can be controlled in 30 hours administered orally once daily." @default.
- W2380887200 created "2016-06-24" @default.
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- W2380887200 date "2002-01-01" @default.
- W2380887200 modified "2023-09-23" @default.
- W2380887200 title "Efficacy of Indapamide Sustained-release in treatment of essential hypertension about delayed and long time" @default.
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