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- W2380920563 abstract "Objective To observe the effect of serum uric acid levels and renal function by exogenous nucleotides in multi-generation rats. Methods Weanling rats(F0) were fed to exogenous nucleotides at the dose of 0,0.01 %,0.04 %,0.16 %,0.64 %,1.28 % for 90 days and then male and female rats mated for 1∶1 pattern. The offspring of F0 was F1. F1 rats were fed to exogenous nucleotides for 90 days after they were weaned. And then go on to the second reproductive experiment. Repeat the progress above until F3 rats were born. After every generation fed for 90 days,blood samples were collected to detect the contents of serum uric acid,urea nitrogen,creatinine,and then the pathologic examination of kidney was performed. Results Serum uric levels of F1,F2,F3 male rats in dose groups were significantly lower than those of control group,but the same result didn't appear in female rats. No renal insufficiency and Pathological changes were found in the four generation rats. Conclusion At the dose of the experiment,supplementing exogenous nucleotides could decrease serum uric acid levels of male descendant rats and renal injury was not been found." @default.
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- W2380920563 date "2009-01-01" @default.
- W2380920563 modified "2023-09-23" @default.
- W2380920563 title "The effect of exogenous nucleotides on serum uric acid levels and renal function in multi-generation rats" @default.
- W2380920563 hasPublicationYear "2009" @default.
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