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- W2380927478 abstract "Objectives To establish the methods for recording calcium-activated potassium channel ( KCa) , voltage-gated potassium channel (KV) and inward rectifier channel (Kir) in pulmonary arterial smooth muscle cells (PASMC). Methods PASMC was acutely isolated by enzyme. Potassium currents were recorded by whole-cell patch- clamp technique. Results (1) High-quality single PASMCs were obtained. A typical single cell was fusiform shape and its cytoplasm was uniform and lucent. (2) KV currents were inhibited by 5 mmol / L 4-AP, Ⅰ-Ⅴ relation curve was shifted downward, KV current density were reduced from ( 133.86 ±7.36) pA / pF to ( 59.09 ±3.35) pA / pF (n=6, P0.05) at 55 mV. (3) KCa currents were inhibited by 1 mmol/ L TEA. Ⅰ-Ⅴ relation curve was shifted downward. KV current density were reduced from (9.03±1.42) pA / pF to (2.12±0.52) pA / pF (n=7, P0.05) at 55 mV. (4) KATP currents were activated by 10 μmol / L nicorandil. I-V relation curve was shifted upward. KV current density were increased from (29.08±5.90) pA / pF to (88.90±7.98) pA / pF (n=10, P0.05) at 50 mV. Conclusions KCa, KV and Kir currents were recorded successfully in rat single PASMC, which offers an effective cell model to explore the pathogenesis of pulmonary artery diseases." @default.
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- W2380927478 date "2009-01-01" @default.
- W2380927478 modified "2023-09-26" @default.
- W2380927478 title "Establishment of recording potassium channel currents in pulmonary arterial smooth muscle cells" @default.
- W2380927478 hasPublicationYear "2009" @default.
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