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- W2380936573 abstract "Aim To discovery novel aminopeptidase N inhibitors as anticancer agents,a new series of cinnamoyl asparagine derivatives were designed and synthesized.Methods The target compounds were synthesized through condensation,hydrolyzation and acidification,followed by cyclization in acetic anhydride then aminolysis.Their inhibitory activities against the enzyme were evaluated in vitro.Results and conclusion Twenty-four novel cinnamoyl asparagines derivatives were synthesized and their structures were comfirmed by 1H-NMR,ESI-MS.Four compounds(6d,6g,6k and 6l) show better potent activities(IC50=12-28 μmol·L-1) against aminopeptidase N,which are worthy of further investigation as lead antitumor compounds." @default.
- W2380936573 created "2016-06-24" @default.
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- W2380936573 date "2009-01-01" @default.
- W2380936573 modified "2023-09-24" @default.
- W2380936573 title "Synthesis and preliminary activity assay in vitro of cinnamoyl asparagines derivatives as aminopeptidase N(APN/CD13) inhibitors" @default.
- W2380936573 hasPublicationYear "2009" @default.
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