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- W2380936973 abstract "Objective To investigate the correlation of the polymorphisms of the TNF-α-308 gene with the susceptibility of gastric cancer. Methods The genetic DNA was extracted from the peripheral blood of 130 normal subjects and 65 gastric cancer patients in Henan Province. TNF-α-308 polymorphisms were analyzed using PCR-restriction fragment length polymorphism(PCR-RFLP). Results The genotypes of TNF-α-308 alleles were G/G, G/A and A/A; the frequencies of genotypes in patients were 86.15%, 13.85%, 0, and the frequencies in controls were 86.92%, 12.31%, 0.77%; contrast the genotype of G/G, TNF-a-308 G/A carriers were at an increase risk of gastric cancer with an odds ratio of 1.8(95%CI: 0.6-4.4), and TNF-α-308 A/A were at an increase risk of gastric cancer with an odds ratio of 2.6(95%CI: 0.8-6.1). Conclusion TNF-α-308 gene polymorphism does not associate with the risk of gastric cancer in this area." @default.
- W2380936973 created "2016-06-24" @default.
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- W2380936973 date "2014-01-01" @default.
- W2380936973 modified "2023-09-23" @default.
- W2380936973 title "Study on the relationship of TNF-α-308 gene polymorphism with gastric cancer" @default.
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