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- W2380962541 abstract "In this paper the effect has been studied of some antitumour drugs(thioproline,cytosine,actinomycin and 5-fluoro-2′-deoxyuridine) acting at different levels onthe membrane fluidity of the normal Chinese hamster lung cell V_(79) and cancer cellV_(79)-B_1.From the spectra obtained the order parameter,mean fluctuation angle,rotational correlation time and microviscosity of cell membrane fatty acid chainbefore and after treatment with antitumour drugs were calculated.It was found thatafter treatment with these drugs the order parameters were raised,the mean fluctua-tion angles were lessened and the rotational correlation times and micro-scopicviscosities were raised,thus lowering cell membrane fluidity.The effects of theseantitumour drugs on tho hy drophobic parts of the fatty acid chain are similar,butthe effect of thioprolino on the surface of the membrane is the largest,while thoseof cytosine,actinomycin and 5-fluoro-2′-deoxyuridine are smaller.The kineticcurves of the order parameters corresponded to the times of the antitumour drugtreatment,were madeFrom these curves it was found that the response of V_(79)-B_1 tothe drugs was faster than V_(79) except for actinomycin." @default.
- W2380962541 created "2016-06-24" @default.
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- W2380962541 date "1984-01-01" @default.
- W2380962541 modified "2023-09-23" @default.
- W2380962541 title "EFFECT OF SOME ANTITUMOUR DRUGS ON THE MEMBRANE FLUIDITY OF THE SPIN-LABELED HAMSTER LUNG NORMAL CELL V_(79) AND CANCER CELL V_(79)-B_1" @default.
- W2380962541 hasPublicationYear "1984" @default.
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