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- W2380967043 abstract "Objective:To observe the effect of Gexia Zhuyu Decoction on fatty acid metabolism associated enzymes in liver of rats with nonalcohlic steatohepatitis(NASH),and to explore the mechanism of preventing NASH with Gexia Zhuyu Decoction.Methods:30 male rats were randomly and respectively divided into the normal group,the model group and the Gexia Zhuyu Decoction group.The rats in the normal group were fed with satandard fodder mixtures,the others with high-fat diet.Meanwhile,the rats in the Gexia Zhuyu Decoction group were fed with Gexia Zhuyu Decoction liquid extract by daily gavage at the dose of 14g/(kg·d),the rats in the normal and model groups were fed with isometrical distilled water by daily gavage.At the end of 12th week,all the rats were put to death.The liver pathological changes were evaluated under light microscope after HE staining,the contents of liver homogenate TG and CHOL were detected with biochemistry assay,the contents of serum free fatty acid(FFA),liver fatty acid synthase(FAS),acetyl CoA carboxylase(ACC),carnitine palmitoyl trans-ferase(CPT) and Stearoyl CoA desat urease(SCD) were measured with ELISA.Results:In this model,the hepatic tissue showed serious fatty change,ballooning degeneration of hepatocytes,with varying degrees of inflammatory cell infiltration and spotty and patchy necrosis inhepatic lobules.The NAFLD activity sore was higher than that in the normal group(P0.01).The amounts of serum FFA,liver homogenate TG and CHOL were enhanced than those in the normal group(P0.01).The contents of liver ACC,FAS were higher(P0.01),but the levels of CPT-1,SCD-1 proteins were lower than those in the normal group.With the treatment of Gexia Zhuyu Decoction,the NAS of rats liver were obviously decreased than that in the model group.The contents of serum FFA,liver TG,CHOL and the expressions of ACC,FAS were obviously decreased than those in the model(P0.01,P0.05),but the expressions of CPT-1and SCD-1 proteins were obviously increased than those in the model(P0.01,P0.05).Conclusions:There is a disorder of fatty acid metabolism in NASH rats induced by high-fat diet,to some degree,Gexia Zhuyu Decoction can correct the disorder of fatty acid metabolic associated enzymes and relieve the injury of fatty acid,which is probably the important mechanism of prevention and treatment from NASH." @default.
- W2380967043 created "2016-06-24" @default.
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- W2380967043 date "2012-01-01" @default.
- W2380967043 modified "2023-09-23" @default.
- W2380967043 title "Effect of Gexia Zhuyu Decoction on Fatty Acid Metabolic Associated Enzymes in Liver of Rats with Nonalcohlic Steatohepatitis" @default.
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