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- W2380971092 abstract "Objective:To study the mechanism of ligustrazine against myocardial ischemia in rats.Methods:The rats were randomly devided into the control,model and ligustrazine treated groups.The model of myocardial ischemia was induced by subcutaneous injection of isoproterenol(ISP,5mg/kg)into rats and by the same dose 24 hours later.Histopathological changes in myocardium was observed.The activities of superoxide dismutase(SOD),glutathion peroxidase(GSH-PX),nitric oxide synthase (NOS) and contents of malondialdehyde(MDA),Ca 2+ and nitric oxide(NO) in the myocardial mitochondria were observed respectively.Results:Ligustrazine could lighten obviously the reaction of denaturation and mecrosis and leukocytes infiltration in rat myocardium damaged by isoproterenol.In the ligustrazine treated group,as compared with those of the model,the activities of SOD、GSH-PX in the myocardial mitochondria increased significantly( P 0.01 or P 0.05),while the activity of NOS and the content of Ca 2+ 、MDA and NO decreased significantly( P 0.01 or P 0.05).Conclusions:Ligustrazine has protective effects on myocardial ischemia injury in rats,which is due to its inhibiting calcium overload,decreasing the activity of NOS and protecting myocardial mitochondria from injury which is caused by NO,scavenging free radicals and anti-lipid peroxydation reaction. Author's address:1.Department of Pharmacy,Jiangxi Medical College,Nanchang 330006,China;2.Department of Biochemistry and Molecular Biology,Jiangxi Medical College,Nanchang 330006,China" @default.
- W2380971092 created "2016-06-24" @default.
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- W2380971092 date "2004-01-01" @default.
- W2380971092 modified "2023-09-25" @default.
- W2380971092 title "Effects of ligustrazine on NO and free radicals of mitochondria in rats with myocardial ischemia" @default.
- W2380971092 hasPublicationYear "2004" @default.
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