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- W2380971145 abstract "Objective:To investigate the protective effects an d the mechanisms of Jidesheng Sheyao(Sy),a Chinese patent medicine,on acute hepatic injury of rats.Methods:48 SD rats were randomly divided into the normal control group,the model group,the high-dose treatment group of Sy and the low-dose treatment group of Sy.All experimental rats except those of the normal control group were given a single dose of Alpha-naphthylisothiocyanate(ANIT) to make a hepatic injury model,The serum biochemical indexes including alanine aminotransferase(ALT),aspartate aminotransferase(AST) and total bilirubin(TBil) of rats were monitored at 72h after the rats were given ANIT,and meanwhile,the contents of malondialdehyde(MDA),Glutathione-SH(GSH),nitric oxide(NO) as well as the activity of Superoxide dismutase(SOD) in serum were detected.The pathological changes of hepatic tissue of the rats were observed.Results:Compared with the model group,the serum levels of ALT of the rats of the low-dose treatment group significantly decreased and the serum levels of GSH obviously increased(P0.05).The hepatic pathological changes of rats of the treatment groups,especially of the low-dose group,were inferior to that of rats of the model group.Conclusion:Jidesheng Sheyao has some protective effects on ANIT-induced acute hepatic injury of rats,one of the mechanisms of which may be related to enhancing antioxidation ability of the rat." @default.
- W2380971145 created "2016-06-24" @default.
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- W2380971145 date "2009-01-01" @default.
- W2380971145 modified "2023-09-24" @default.
- W2380971145 title "The initial study on protective effects and mechanisms of jidesheng Sheyao on acute hepatic injury of rats" @default.
- W2380971145 hasPublicationYear "2009" @default.
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