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- W2380972957 abstract "Objective To investigate the expression and their mutual relation of the CyclinACDK2 gene in human non-small-cell lung cancer(NSCLC),and to study their role in the carcinogenesisdevelopmentlymphy nodes metastases and prognosis of NSCLC.Methods The expression of cyclin A and CDK2 was tested by immunohistochemical method(two steps method) in 40 cases of NSCLC(21 cases with lymphy nodes metastases),11 cases of bronchial epithelium dysplasia and 9 specimens of lymph nodes metastases.The 3-years survival rate was observed in the follow-up period of 40 cases of NSCLC.Results In bronchial epithelium dysplasia,NSCLC without and with lymphy nodes metastases,and specimens of lymphy nodes metastases,the positive rate of Cyclin A protein was 9.09%(1/11),31.58%(6/19),80.95%(17/21) and 66.67%(6/9)respectively,the positive rate of CDK2 protein was 9.09%(1/11),36.84%(7/19),76.19%(16/21) and 77.78%(7/9) respectively.The expression of Cyclin A and CDK2 was significantly different between NSCLC with or without lymphy nodes metastases(P0.05).The 3-year survival rate was 21.74%(5/23) for positive Cyclin A patients and 58.82%(10/17) for negative Cyclin A patients,showing a significant difference(P0.05).The 3-year survival rate was 17.39%(4/23) for positive CDK2 patients and 64.71%(11/17) for negative CDK2 patients,showing a significant difference(P0.05).Cyclin A expression positively correlated with CDK2 expression(~2=19.22,P0.001,Pearson=(0.570)).Conclusion Cyclin A and CDK2 might play an important role in the carcinogenesis,development,and lymphy nodes metastases of NSCLC.Up-regulation of Cyclin A and CDK2 expression indicates a poor prognosis for patients with NSCLC." @default.
- W2380972957 created "2016-06-24" @default.
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- W2380972957 date "2005-01-01" @default.
- W2380972957 modified "2023-09-26" @default.
- W2380972957 title "Significance of Cyclin ACDK2 Expression in Non-Small-Cell Lung Cancer" @default.
- W2380972957 hasPublicationYear "2005" @default.
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