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- W2380982467 abstract "OBJECTIVE:To evaluate the efficacy and safety of homoharringtonine(HHT)for acute promyelocytic leukemia(APL). METHODS:Retrieved from PubMed,The Cochrane Library,EMbase,VIP,Wanfang database,CBM and CNKI,randomized controlled trials about HHT for APL were collected. Two reviewers independently screened literature according to the inclusion and exclusion criteria,extracted data,and assessed methodological quality. Meta-analysis was performed by using RevMan5.2 statistical sofetware. RESULTS:7 trials were included,involving a total of 393 patients. Results of Meta-analysis showed that:there was no statistical difference in either CR rate of APL [RR=1.07,95%CI(1.00,1.14),P=0.06] or the incidence of infection during myelosuppression period [RR=0.83,95% CI(0.48,1.42),P=0.49] between HHT group and control group;the time to achieve CR [MD=-3.47,95%CI(-5.57,-1.38),P=0.001],peak value of WBC [MD=-8.26,95%CI(-25.49,8.97),P=0.35],plasma transfusion [MD=-334.32,95%CI(-457.30,-211.33),P0.000],platelet transfusion [MD=-25.23,95%CI(-41.02,-9.43),P=0.002],medical cost [SMD=-1.99,95%CI(-3.93,-0.06),P=0.04] in HHT group were all better than in control group. CONCLUSIONS:The regimens of HHT combined with ATRA and ATO is safe and effective for APL and reduce medical costs. The conclusion still needs large with high quality RCT confirmed." @default.
- W2380982467 created "2016-06-24" @default.
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- W2380982467 date "2014-01-01" @default.
- W2380982467 modified "2023-09-23" @default.
- W2380982467 title "Homoharringtonine for Acute Promyelocytic Leukemia:A Systematic Review" @default.
- W2380982467 hasPublicationYear "2014" @default.
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