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- W2380988557 abstract "Objective To investigate the effect of a combined therapeutic scheme based on amlodipine and its influence on the blood pressure criteria and vascular events in hypertensive patients.MethodsA multi-centre, randomized, open, controlled and blinded-endpoint study was carried out.On the basis of informed consent, the hypertensive patients aged from 50 to 79 with at least one cardiovascular risk factor, were randomly divided into the group of amlodipine combined with amiloride compound (group A, n=5805) and the group of amlodipine combined with telmisartan (group B,n=5805).The primary endpoint under the investigation was cardiovascular compound event, which was treated and followed up for four years.ResultsThere were 13 134 cases followed up from Oct. 2007 to Oct. 2008 in 180 cooperative units, among which the data of 11 610 cases were analyzed initially.The result showed that the average baseline blood pressure was 157/93 mm Hg (1 mm Hg=0.133 kPa).On 8th week after the random treatment, the blood pressure decreased to 133.0/80.9 mm Hg in group A and 132.9/80.3 mm Hg in group B.The rate of blood pressure control was 71.5% in group A and 72.0% in group B on 8th week.ConclusionThe combined blood pressure lowering therapy based on amlodipine has a good effect on controlling blood pressure." @default.
- W2380988557 created "2016-06-24" @default.
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- W2380988557 date "2008-01-01" @default.
- W2380988557 modified "2023-09-25" @default.
- W2380988557 title "CHIEF:Study on Chinese hypertension intervention efficacy—A stage report-1 on a clinical randomized trial of combined therapeutic scheme for hypertension based on calcium antagonist in initial low dose" @default.
- W2380988557 hasPublicationYear "2008" @default.
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