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- W2380996680 abstract "Objective To investigate the effects of dehydroepiandrosterone(DHEA)on rat osteoblasts and IL-1β in vitro.Methods Rat's osteoblasts were separated and cultured in vitro.Osteoblasts of first generation were treated with DHEA in different concentration(10-5,10-7,10-9mmol/L)for 72 hours,E2 in 10-8mmol/l was adopted as positive control group,and blank control group was also set up.The biological characteristics of osteoblasts were evaluated by phase-contrast microscopy and alkaline phosphatase(ALP)histochemistry.Proliferation ability of osteoblasts was examined by MTT,activity of ALP was determined by PNPP.Level of IL-1β in DHEA culture solution was determined by ELISA simultaneously.Results Proliferation and ALP activity of osteoblasts treated with DHEA in different concentration were raised,especially treated with DHEA in 10-7mmol/l(P0.01),which was similar to E2(P0.05).ALP activity of unitary cell population treated with DHEA in 10-9mmol/l was higher than blank control group(P0.05).Downtrend of IL-1β could be seen in each DHEA group,and negative correlation between proliferation ability or ALP activity of OBs and IL-1β could also be found.Conclusion DHEA could stimulate proliferation and raise ALP activity of rat's osteoblasts in vitro,whose mechanism might inhabit the expression of IL-1β." @default.
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- W2380996680 date "2008-01-01" @default.
- W2380996680 modified "2023-09-28" @default.
- W2380996680 title "Effects of Dehydroepiandrosterone on Metabolism of Rat Osteoblasts and IL-1β in Vitro" @default.
- W2380996680 hasPublicationYear "2008" @default.
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