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- W2380998505 abstract "The technology is first discovered in plant the nematode Caenorhabditis elegans.The production of small interfering RNAs(siRNAs) that bind to and induce the degradation of specific endogenous mRNAs is now recognized as a mechanism widely employed by eukaryotic cells to inhibit protein production at a posttranscriptional level.The endogenous siRNAs that upon 23-base double-stranded RNA oligonucleotides,produced from much larger RNAs that upon binding to target mRNAs recruit RNases to a protein complex that degrades the targeted mRNA.RNAi(RNA interference) has recently emerged as a powerful reverse genetic tool to silence gene expression in multiple organisms.Methods for expressing siRNAs in cells in culture and in vivo using viral vectors,and for transfecting cells with synthetic siRNAs,have been developed and are being used to establish the functions of specific proteins in various cell types and organisms.RNA interference methods provide several major advantages over prior methods (antisenseDNA or antibody-based technipues) for suppressing gene expression.The general and sepuence-specific inhibitory effects of RNAi that will be selective,long-term,and systemic to modulate gene targets mentioned in similar reports have caused much concern about its effectiveness in mammals and its eventual use as a therapeutic mordality.It is certain that the ability of RNAi in mammals to silence specific genes,either when transfected directly as siRNAs or when generated from DNA vectors,will undoubtedly accelerate the study of gene function and might also be used as a potentially useful method to develop highly gene-specific therapeutic methods.Pharmacologists have long dreamed of the ability to selectively antagonize or to eliminate the function of individual proteins—RNAi technology may eventrally make that dream a reality." @default.
- W2380998505 created "2016-06-24" @default.
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- W2380998505 date "2008-01-01" @default.
- W2380998505 modified "2023-09-23" @default.
- W2380998505 title "RNA Interference Technology" @default.
- W2380998505 hasPublicationYear "2008" @default.
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