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- W2381026954 abstract "Objective To explore the immunology characteristic of BALB/c mice and Wistar rats to Mycobacterium marinum pathogen isolated from a clinic case, and to improve the comprehension for the clinical infection with Mycobacterium marinum. Methods Took a strain from one case infected in a hand middle finger with Mycobacterium marinum, then cultivate it by improved Roche Media, in constant temperature, 28-32 ℃, away from light for 7-10 days. We picked up bacterial colonies from culture media, and prepared bacterial solution by McFarland turbidimetry. Thirty male BALB/c mice were selected and divided them into three groups randomly, experimental group A and group B, control group E. Group A and group B mice were infected with 0.1 ml germ liquid by caudal vein and abdominal cavity injected(germ density, 3 × 108 cfu/ml), respectively. Control group E were received 0.9% sodium chloride 0.1 ml liquid by caudal vein. All of mice were executed after infection for 4 weeks, and collected 1 ml blood to detect the IL-2, IL-4, IL-10 and IL-12 by ELISA kits. Thirty male Wistar rats were divided into three groups randomly, experimental group C and group D, control group F. Group C were injected 0.1 ml liquid by caudal vein, group D were dropped 0.1 ml liquid in damaged skin near the root of tail, respectively. Control group F were given 0.9% sodium chloride 0.1 ml liquid by caudal vein. All of rats were sacrificed after infected for 4 weeks, and 2 ml blood was taken from rats, respectively. The blood were detected the C3, C4, CRP, IgA, IgG and IgM by automatic biochemistry machine. Results The expression of IL-2, IL-10 and IL-12 in serum is no statistics difference between group A and group B(t = 0.486-0.978, P = 0.341-0.633), whereas the IL-4 has statistics difference in group A and group B(t = 2.534, P = 0.021). While IL-2, IL-4, IL-10 and IL-12 has statistics difference in experimental group A and group B respectively compare with control group E(t = 5.763-17.283, P = 0.001-0.009). The activity of C3 and C4, as well as the secretion of CRP, IgA, IgG and IgM have statistics difference in group C compare with group D and control group F respectively(t = 2.206-7.512, P = 0.000-0.007), but it has no difference in experimental group D and control group F(t = 0.570-1.239, P = 0.136-0.576). Conclusions Mycobacterium marinum is a conditional pathogenic bacterium. The expression of interleukins and immunoglobulin are increased, and the complement activity of C3 and C4 are reinforcing in BALB/c and Wistar infected with Mycobacterium marinum. But the local infection can not cause the strength of complement activity and the increase of immunoglobulin." @default.
- W2381026954 created "2016-06-24" @default.
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- W2381026954 date "2013-01-01" @default.
- W2381026954 modified "2023-09-27" @default.
- W2381026954 title "Pathopoiesis empirical study on Mycobacterium marinum clinical isolate from a infected case for BALB/c mice and Wistar rats" @default.
- W2381026954 hasPublicationYear "2013" @default.
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