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• W2381036291 abstract "Objective To evaluate the therapeutic effects of transplantation of haploidentical allogeneic stem cells, and the difference between those collected from peripheral blood and from bone marrow. Methods Fifty-six patients with leukemia, admitted to Department of Hematology of Xinqiao Hospital from Jun. 2006 to Dec. 2008, were enrolled as recipients who received transplantation of haploidentical allogeneic stem cells, with their family members including, parents, brothers or sisters as the donors. All donors were given subcutaneous injection of granulocyte colony stimulating factor (G-CSF) for stem cells mobilization. Subsequently, stem cells in peripheral blood were isolated and collected with CS-3000 plus blood cell separation machine when the number of mononuclear cells (MNC) reached over 4.0×109 per liter, and they wer given to recipients within an hour. According to different collection methods in collecting stem cells from bone marrow, 56 donors were divided into 3 groups: bone marrow of Group 1 (n=5) was filtered with Lu Dao-pei's method (filter bone marrow with an injection needle), that of Group 2 (n=6) was filtered with Thomas' method (filter bone marrow with stainless steel strainer), and that of Group 3 (n=43) was filtered with the improved method (syringe needle and stainless steel strainer were replaced with transfusion set with stainless steel mesh). The erythrocytes of bone marrow should be removed by hydroxyethyl starch (HES) precipitation when major ABO incompatibility was found, while the plasma should be removed when there was minor ABO incompatibility. The stem cells were isolated from bone marrow and infused to recipients within 4 hours after collection. Results The median volume of collected peripheral blood was 56ml, the median amount of MNCs was 5.15×108/kg, and the median amount of CD34+ cells was 5.80×106/kg, and the median volume of 950ml of bone marrow, including a median number of 10.31×108/kg of nucleated cells and a median number of 11.33×106/kg of CD34+ cells, were collected from 56 donors. A total amount of CD34+ cells reached to 13.42×106/kg as obtained from peripheral blood and bone marrow. The quality of nucleated cells and CD34+ cells showed no significant difference as isolated by the 3 different methods. Major ABO imcompatibility was found in 15 cases and minor ABO imcompatibility in 17 cases, while the stem cells were effectively isolated from them. Among 56 recipients received stem cell transplantation, 2 died of intracranial hemorrhage 21 days after transplantation, and in 54 patients full donor chimerism developed on day 30 after transplantation and achieved complete hematopoietic reconstitution. Conclusions Transplantation of haploidentical allogeneic stem cells, collected from peripheral blood and bone marrow, may lead to a complete hematopoietic reconstitution in the patient with leukemia. The transfusion apparatus with filter as used in the present study for stem cell collection is feasible and effective, with which the quality of nucleated cells and CD34+ cells isolated is the same compared with that isolated with traditional methods." @default.
• W2381036291 created "2016-06-24" @default.
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• W2381036291 date "2010-01-01" @default.
• W2381036291 modified "2023-09-23" @default.
• W2381036291 title "Evaluation of efficacy of transplantation of haploidentical allogeneic stem cells collected from peripheral blood and bone marrow" @default.
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