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- W2381043885 abstract "Objective To investigate the effects of erythropoietin(Epo) on cell apoptosis induced by Aβ25-35. Methods SH-SY5Y cells were performed serial subcultivation,and entered into experiment during the exponential phase of growth.The viability of SH-SY5Y cells 24 h after induction by Aβ25-35 with different concentrations were detected by MTT assay,and the morphology and levels of cleaved caspase-3 and caspase-3 24 h after induction by 20 μmol/L Aβ25-35 were observed and examined by Hoechst 33258 nucleus staining and Western blotting,respectively.After pretreatment with Epo of different concentrations for 3 h,the cell viability,morphology,and levels of cleaved caspase-3 and caspase-3 24 h after induction by 20 μmol/L Aβ25-35 were detected with the corresponding methods. ResultsIt was revealed by MTT assay that 24 h after treatment with Aβ25-35 of different concentrations,the viability of SH-SY5Y cells was significantly decreased in a dose-dependent manner(P0.05),and various concentration of Epo could significantly prevent the cell viability induced by Aβ25-35(P0.05).Pretreatment with 10 U Epo could significantly inhibit the viability decrease induced by Aβ25-35(P0.05).It was indicated by Hoechst 33258 nucleus staining that pretreatment with 10 U Epo could significantly reduce the cell apoptosis induced by Aβ25-35(P0.05).Results of Western blotting showed that pretreatment with 10 U Epo could inhibit the increased expression of cleaved caspase-3 induced by Aβ25-35(P0.05). Conclusion Epo may have protective effect on cell apoptosis induced by Aβ25-35 via inhibiting the expression of cleaved caspase-3.Thus,it provides an important theoretic basis for the study of pathogenesis and management of Alzheimer's disease." @default.
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- W2381043885 date "2007-01-01" @default.
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- W2381043885 title "Effects of erythropoietin on cell apoptosis induced by β-amyloid peptide" @default.
- W2381043885 hasPublicationYear "2007" @default.
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