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- W2381077158 abstract "Objective:To investigate the effect of the Three-clearing Hypoglycemic Formula(Sanqing Jiangtang Fang) on the blood glucose and blood lipids in type 2 diabetic rats.Method:Ten rats were selected randomly from 82 male Wistar rats to form the normal group(group C).With high fat forage diet of four weeks,the rest 72 rats were injected of small dose of streptozotocin(STZ) intraperitioneally twice to establish rats model with type 2 diabetes.Based on fasting blood sugar levels,the model rats were randomly divided into group treated with high dose of Three-clearing Hypoglycemic Formula(group SG),group treated with middle dose of Three-clearing Hypoglycemic Formula(group SZ),group treated with low dose of Three-clearing Hypoglycemic Formula(group SD),model control group(group M),group treated with acarbose(group A) and group treated with rosiglitazone(group L).Group SG,group SZ and group SD were administrated with water extracts of Three-clearing Hypoglycemic Formula respectively.Group M was administrated with normal saline.Group A was administrated with acarbose.Compared with group A,group L was administrated with equivalent dosage of rosiglitazone.Thesugar tolerances were measured 2 weeks and 4 weeks before and after treatment respectively.Four weeks after treatment,blood was obtained from aorta of rats.blood lipid and hepatic/renal function were tested for further comparisons.Result:① Four weeks after medicine treatment,there was significant difference between group SD and group M regarding fasting blood glucose levels(P=0.011);② Four weeks after medicine treatment,there was significant difference in SD group regarding 2 hours-postprandial glucose levels,compared with group SG,group M,group A and group L(P 0.05);③ Four weeks after medicine treatment,there were no significant difference between each group regarding HDL-c,LDL-c,ALT,AST and crestine levels.Comparing group SZ,group SD,group M and group C,there was significant statistics regarding CHO level(P 0.05).Comparing group SZ,group SD,group A and group C,there was significant difference regarding TG level(P 0.05).Comparing group C with other groups,there was significant difference regarding BUN level(P 0.05).Conclusion:Low dose of Three-clearing Hypoglycemic Formula has better hypoglycemic effect regarding fasting blood glucose and 2 hours-postprandial glucose." @default.
- W2381077158 created "2016-06-24" @default.
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- W2381077158 date "2011-01-01" @default.
- W2381077158 modified "2023-09-24" @default.
- W2381077158 title "Effects of Three-clearing Hypoglycemic Formula on Blood Glucose and Blood Lipid in Experimental Rats with Type 2 Diabetes" @default.
- W2381077158 hasPublicationYear "2011" @default.
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