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- W2381084150 abstract "The pharmacokinetics of famotidine was studied after a single oral dose of 40mg to 6 men(age 46± s 15 a)with liver cirrhosis and 6 men(age 49± 10 a) with liver cancer.A one-compartment open model was adopted in the analysis. The plasma T1/2 was 3.8 ±1.1 h, Cmax was 102±14 ng/mL,AUC was 604±197 ng/(mL·h). Mean renal and total body clearance were 416±128 and 579 ±117 mL/min,respectively. About 33% ± 9%(13±4 mg)of the dose were recovered as unchanged famotidine in urine within 24 h.No significant differences were found in all pharmacokinetic parameters between 10 healthy volunteers and 12 patients with liver diseases. Thus no reduction in drug dosage would be necessary in patients with liver diseases." @default.
- W2381084150 created "2016-06-24" @default.
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- W2381084150 date "1994-01-01" @default.
- W2381084150 modified "2023-09-23" @default.
- W2381084150 title "Pharmacokinetics of famotidine in patients with liver diseases" @default.
- W2381084150 hasPublicationYear "1994" @default.
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