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- W2381086185 abstract "Objective To compare the antifungal activities of voriconazole against Candida krusei with fluconazole and amphotericin B in vivo.Methods The immunocompromising guinea pigs models were deeply infected with Candida krusei,which in different groups were treated by voriconazole 10 mg/kg orally twice daily,voriconazole 5 mg/kg orally twice daily,fluconazole 20 mg/kg orally twice daily and amphotericin B 1 mg/kg i.p.on alternate days,control group was treated by 0.9% NS 0.5 ml orally twice daily,respectively for 7 days.The mortality and tissue burden of each group were observed and compared.Results All of the tested organs in control groups were seriously infected.Among all the five groups,the tissue burden and the cumulative mortality (0%) of voriconazole 10 mg group were the lowest.Compared with that in the control group,the application of voriconazole (10mg/kg orally twice daily) reduced the tissue burdens in four organs (lung,liver,kidney and brain) as much as 100-fold (P0.01).The tissue burdens and mortalities of voriconazole 5 mg group were similar to that of control group,without significant difference between two groups.The tissue burden of fluconazole group was similar to that of control group,and mortality of fluconazole group (40%) was just a little lower than that of control group,without significant difference between two groups (P0.05).Comparing voriconazole 10 mg group with amphotericin B group,in whole sense,the tissue burdens and mortalities of both group were similar,and were significantly different to the control group(P0.01).Conclusion Voroconazole could effectively inhibit the growth of Candida krusei in the infected organs of the immunocompromising guinea pigs.For treating infections caused by Candida krusei,the efficacy of voriconazole was much better than that of fluconazole,similar to that of amphotericin B.Considering the common and serious adverse events of amphotericin B,voriconazole may be more predominant when you choice the drugs in clinic.Voriconazole revealed its antifungal activity by a dose-dependent pattern in vivo." @default.
- W2381086185 created "2016-06-24" @default.
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- W2381086185 date "2006-01-01" @default.
- W2381086185 modified "2023-09-23" @default.
- W2381086185 title "Comparative Studies of the Antifungal Activities of Voriconazole,Fluconazole and Amphotericin B Against Candida Krusei in Vivo" @default.
- W2381086185 hasPublicationYear "2006" @default.
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