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- W2381099457 abstract "In order to enhance the stability of alginate hydrogel in salt solutions and to improve sustained drug release,covalently cross-linked alginic acid gel was synthesized through an esterification of sodium alginate with polyethylene glycol(PEG200)in an aqueous solution,using p-toluenesulfonic acid as a catalyst.Products were confirmed by infrared spectroscopy,thermal analysis and X-ray diffraction analysis.Compared with ionic crosslinked calcium alginate gel,the covalently crosslinked alginic acid gels show a stable structure in bionic body fluids,and the complete degradation time in the bionic body fluids sustains for 60 days.Gels are used as drug vehicles for loading of hydrophilic bovine serum albumin.It is observed that the covalently crosslinked alginic acid gel displays loading rate as high as 11.5%,and obvious sustained slow-release and pH responsiveness.The covalently cross-linked alginic acid gels have application prospects as drug carriers for pH controlled and sustained release." @default.
- W2381099457 created "2016-06-24" @default.
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- W2381099457 date "2015-01-01" @default.
- W2381099457 modified "2023-09-24" @default.
- W2381099457 title "Preparation and Sustained Drug Release of Alginic Acid Gel Covalently Cross-linked by Polyethylene Glycol" @default.
- W2381099457 hasPublicationYear "2015" @default.
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